Resveratrol is a polyphenol with multiple health benefits that is found in plant-based foods such as red grapes, dark berries, plums, nuts, apples, black olives, capers, red wine and cocoa, foods common in the Mediterranean Diet. Resveratrol is actually a stilbenol derived from stilbene, a plant compound that has cell-protecting properties. In the 1990s resveratrol was mentioned as a potential answer to the “French Paradox,” the puzzling finding that French people eat so many high fat dairy and meat foods, yet have lower risk of heart disease than do people in the US. Later, resveratrol was characterized as a potential chemoprotective molecule. Fast forward to the present day and resveratrol is one of the most studied polyphenols.
Resveratrol is well known for its anti-inflammatory, antioxidant, antibacterial and antiviral properties, but more current emerging research highlights many more exciting health benefits in the fields of oncology (cancer treatment), cardiology, neurology and even mitochondrial function, obesity and diabetes.
In cancer, resveratrol has been found to downregulate HIF-1α, a transcription factor that regulates genes that are overly expressed during hypoxia and promotes chemotherapy resistance and metastatic spread in cancer cells. This study also found resveratrol with anticancer drugs may improve the drug’s effectiveness while also lowering toxicity and side effects.
Resveratrol has also been found to have other major anti-cancer benefits:
• activate tumor suppressive genes
• suppress cell proliferation
• induce apoptosis
• inhibit angiogenesis
• modulates cell signaling molecules.
• autophagy “self-eating” of cancer cells which inhibits tumor formation
• suppresses cancer progression,
• enhances DNA repair and the targeting of cancer stem cells (especially important for recurrence prevention).
Resveratrol also contributes to changes associated with improving longevity:
• Increased insulin sensitivity,
• increased mitochondrial number and improved motor function
• Reduced insulin growth factor-1 (IGF-1)
• Increased AMP-activated protein kinase a key player in obesity, type 2 diabetes, and metabolic syndrome
• Relieved the effects of the high calorie diets
• Activates sirtuins (SIR2 and SIRT1) important in cellular longevity and protection of nerve cells
• Modulation of liver apolipoprotein and lipid synthesis and
• inhibition of platelet aggregation and protection against atherosclerosis
• Numerous anti-inflammatory properties include inhibiting synthesis and release of pro-inflammatory mediators, modifying eicosanoid synthesis (which are often associated with disease, including inflammatory disease and cancer), and inhibiting activated immune cells.
I selected TruResveratrol™ Complex for our Truth for Health Store because it is unique in providing a complete bioflavonoid complex with resveratrol, quercetin, and pterostilbene. These three antioxidants work together synergistically. Pterostilbene is methylated resveratrol, a bio-optimized form that complements resveratrol and quercetin. This methylation results in dramatically higher metabolic stability in the liver, improves intestinal absorption and facilitates membrane transport compared to unmethylated resveratrol and quercetin. All of these properties aid in the absorption of resveratrol.
Together this combination and improved bioavailability pack quite a punch! That’s why I am pleased to be able to provide TruResveratrol™ Complex for an exceptionally high quality resveratrol formulation as part of our commitment to help you improve your health and resilience.
To your improving health!
Elizabeth Lee Vliet, MD
All Truth for Health Foundation Formulas are Meet or Exceed Quality Standards set by FDA Current Good Manufacturing Practices (cGMP). For more information, references from studies are listed in the Product Data Sheet.
Under medical practice regulations, we are unable to answer individual medical questions or make specific individual supplement recommendations for people who are not established patients of Dr. Vliet’s independent medical practice. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
