Association of American Physicians and Surgeons Published October 4, 2021
Outcome Reporting Bias in COVID-19 mRNA Vaccine Clinical Trials
by Ronald B. Brown School of Public Health and Health Systems, University of Waterloo, Waterloo, ON N2L3G1, Canada Academic Editor: Edgaras StankevičiusMedicina2021, 57(3), 199; https://doi.org/10.3390/medicina57030199 Received: 13 January 2021 / Revised: 15 February 2021 / Accepted: 22 February 2021 / Published: 26 February 2021 Abstract Relative risk reduction and absolute risk reduction measures in the evaluation of clinical trial data are poorly understood by …
Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk reduction and number needed to treat
Alexandra Barratt 1, Peter C Wyer, Rose Hatala, Thomas McGinn, Antonio L Dans, Sheri Keitz, Virginia Moyer, Gordon Guyatt For, Evidence-Based Medicine Teaching Tips Working GroupAffiliations expand PMID: 15313996 PMCID: PMC509050 DOI: 10.1503/cmaj.1021197 Physicians, patients and policy-makers are influenced not only by the results of studies but also by how authors present the results.1,2,3,4 Depending on which measures of effect authors choose, the impact of an intervention may appear …
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies
Wen Shi Lee 1, Adam K Wheatley 1 2, Stephen J Kent 3 4 5, Brandon J DeKosky 6 7 8Affiliations expand PMID: 32908214 DOI: 10.1038/s41564-020-00789-5 Abstract Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). Previous respiratory …
Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity
James Lyons-Weiler 1Affiliations expand PMID: 32292901 PMCID: PMC7142689 DOI: 10.1016/j.jtauto.2020.100051 Free PMC article Abstract Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. Failure of SARS and MERS vaccines in animal trials involved pathogenesis consistent with an immunological priming that could involve autoimmunity in lung tissues due to previous exposure to the SARS and …
Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus
Chien-Te Tseng 1, Elena Sbrana, Naoko Iwata-Yoshikawa, Patrick C Newman, Tania Garron, Robert L Atmar, Clarence J Peters, Robert B Couch Erratum in PLoS One. 2012;7(8). doi:10.1371/annotation/2965cfae-b77d-4014-8b7b-236e01a35492 Abstract Background: Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development …
Why COVID-19 vaccines might affect fertility
Author: Roxana Bruno, Biochemistry PhD in Immunology. Striking similarity between human syncytins and the sars-cov-2 spike protein: Why covid-19 vaccines might affect fertility SUMMARY COVID-19 vaccines carry the spike protein (S or «Spike») of the SARS-CoV-2 virus as an alleged antigen to trigger the immune response, which shares high genetic and protein similarity with two …
Life Insurance CEO Says Deaths Up 40% Among Those Aged 18-64
Originally published by Zero Hedge The death rate for those aged 18-64 has risen an astonishing 40% over pre-pandemic levels, according to the CEO of Indianapolis-based insurance company OneAmerica. “We are seeing, right now, the highest death rates we have seen in the history of this business – not just at OneAmerica,” said Scott Davison, head of …